Bioactive Small Molecules
Cayman Chemical 25I-NBFhydrochlorIde 5mg
A 2C-I derivative that acts as a partial agonist of human 5-HT2A receptors (Ki = 0.26 nM; EC50 = 1.6 nM); intended for forensic and research applications
Cayman Chemical ANTIBODY XMD16-5 1mg
A TNK2 inhibitor (IC50 = 0.38 µM); decreases viability of Ba/F3 cells expressing the oncogenic TNK2 D163E and R806Q mutant proteins (IC50s = 16 and 77 nM, respectively)
Sigma Aldrich Fine Chemicals Biosciences HIV Inhibitor CADA - Calbi
A cell-permeable macrocyle cyclotriazadisulfonamide derivative compound that inhibits HIV replication (IC50 300 nM to 3.3 181M) and entry into cells by blocking co-translational translocation of nascent CD4 across endoplasmic reticulum membranes. Its action appears to be highly selective in reducing the expression of human CD4 and it does not affect the level of any other cell surface marker studied. Does not affect CD4 mRNA levels in cells. Shown to be effective against HIV-1 subtypes A to H AE and O and human herpesvirus 7 (HHV-7 IC50 300 nM to 1.5 181M) in T-cell lines and PBMCs. Also reported to block X4 HIV-1 NL4.3 and R5 SIVmac251 laboratory strains infection in human T cells. Can act synergistically with cellulose acetate phthalate (CAP) and other anti-HIV drugs to inhibit HIV-1 and SIV infections.
Cayman Chemical ANTIBODY RO4987655 5mg
A MEK inhibitor (IC50 = 5 nM); selective for MEK over 400 kinases at 10 µM; inhibits proliferation of COLO 205, HT-29, QG56, MIA PaCa-2, and C32 cells (IC50s = 0.86, 1.7, 9.5, 3.3, and 8.4 nM, respectively); reduces tumor growth in a variety of mouse xenograft models; inhibits the phosphorylation of ERK in tumor tissue in an HT-29 mouse xenograft model at 6.25 mg/kg per day; acts synergistically with everolimus to reduce tumor volume in an HCT116 mouse xenograft model
Cayman Chemical SaIkosaponIn F 5mg
A triterpenoid saponin and an antagonist of TRPA1; inhibits polygodial- or AITC-induced calcium flux in HEK293 cells expressing human TRPA1 from 0.5-1.5 µM
STEMCELL Technologies GANT 58, Size: 10 mg
GANT 58 inhibits the Hedgehog signaling pathway downstream of Smoothened and Suppressor of Fused (SUFU) leading to GLI1 nuclear accumulation (Joo et al.; Stanton & Peng). GANT 58 demonstrates antiproliferative and antitumor activity in vivo (Beauchamp et al.; Joo et al.).CANCER RESEARCH · Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).· Inhibits prostate cancer tumor growth (Lauth et al.).· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
Cayman Chemical ANTIBODY CL4F8-6 1mg
An ionizable cationic lipid that has been used in combination with other lipids in the formation of LNPs; LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver after intravenous administration; LNPs containing CL4F8-6 and encapsulating mCas9 and sgTtr have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum levels of TTR
Cayman Chemical ANTIBODY Cy3-SE 1mg
An amine-reactive fluorescent probe; ex/em = 550/570 nm, respectively; has commonly been used to label nucleic acids
Medchemexpress LLC LLY-284 50mg | 2226515-75-7 | 50MG
LLY-284 is the diastereomer of LLY-283 with much less active LLY-283 is a potent inhibitor of PRMT5 LLY-284 has the potential for the research of cancer diseases[1
Medchemexpress LLC S 18986 | 175340-20-2 | 99.9% | 224.28 | 500 MG
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. It exhibits cognitive enhancing properties in rodents, activating the release of noradrenaline and acetylcholine in the rat hippocampus and improving memory in object-recognition tests.
- Selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors.
- Shows cognitive enhancing properties in rodents.
- Activates the release of noradrenaline and acetylcholine in rat hippocampus.
- Enhances rat memory in object-recognition tests.
- Exhibits robust memory-enhancing effects in middle-aged animals compared with aged ones.
- Shows antiamnesic properties in middle-aged rodents in spatial memory models.
- Significantly increases both the induction and maintenance of 4 and 20 bursts tetanus-evoked potentiation at dosages of 5-50 mg/kg (i.p.).
Cayman Chemical TrImIpramIn-d3maleate 5mg
An internal standard for the quantification of trimipramine by GC- or LC-MS
Cayman Chemical ANTIBODY CuspIn-1 25mg
A small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA-patient fibroblasts by 50% at 18 µM; increases phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation
TARGETMOL CHEMICALS INC NSC 23766 TRIHYDROCHLORI 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50 ~50 uM); no inhibitory for the closely related targets RhoA or Cdc42. purity: 99%
Cayman Chemical ANTIBODY ARV-766 1mg
A PROTAC that drives androgen receptor degradation (DC50 = <1 nM); inhibits tumor growth in various LNCaP and VCaP prostate cancer mouse xenograft models, including an enzalutamide-insensitive, non-castrated VCaP model
Medchemexpress LLC TD-0212 TFA 25mg | 1073549-11-7 | 25 MG
TD-0212 TFA is the trifluoroacetic acid (TFA) salt of TD-0212, an orally active small molecule with dual activity as an angiotensin II type 1 (AT1) receptor antagonist and a neprilysin (NEP) inhibitor. It is supplied as a white to off-white solid for research use.
- CAS number: 1073549-11-7.
- Dual pharmacology: AT1 antagonist (pKi 8.9) and NEP inhibitor (pIC50 9.2).
- Molecular formula: C30H35F4N3O6S; molecular weight: 641.67 g/mol.
- Purity: 98.44%.
- Solubility: DMSO 125 mg/mL; in vivo vehicle protocols achieve ≥2.08 mg/mL.
- Storage: solid at -20°C; in solvent -80°C (6 months) or -20°C (1 month).