Bioactive Small Molecules
AdipoGen UBS109 (5 x 1 mg)
Chemical. CAS: 1258513-40-4. Formula: C18H17N3O. MW: 291.4. Most water soluble synthetic monocarbonyl analog of curcumin (MAC) for in vitro and in vivo application. Potently inhibits NF-kappaB and its nuclear translocation by suppressing IKK-alpha and IKK-beta, consequently leading to apoptosis. Potent DNA hypomethylating agent. Inhibits HSP90 and NF-kappaB leading to downregulation of DNA methyltransferase-1 (DNMT-1) expression. Cytotoxic against several cancers in vitro and in vivo. Shows excellent activity against xenografts of head and neck squamous cell carcinoma, pancreatic cancer, colon cancer and breast cancer. Antiangiogenic agent. Induces the downregulation of HIF-1alpha, HSP90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.
![Medchemexpress LLC Urea, N-[1-[(2-amino-4-pyridinyl)methyl]-1H-indol-4-yl]-N'-(5-bromo-2-methoxyphenyl)- | 900573-88-8 | 99.0% | 466.33 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Urea, N-[1-[(2-amino-4-pyridinyl)methyl]-1H-indol-4-yl]-N'-(5-bromo-2-methoxyphenyl)- | 900573-88-8 | 99.0% | 466.33 | 25 MG
JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ, and EphB4 with potent anti-cancer activity. It is stable in preclinical and human liver microsomes and is rapidly absorbed after oral administration, demonstrating extensive tissue distribution with preferred uptake into lung tissue.
- Orally available multi-kinase inhibitor targeting VEGFR2, PDGFRβ, and EphB4
- Demonstrates potent anti-cancer activity
- Stable across various preclinical and human liver microsomes
- Rapidly absorbed after oral administration, reaching Cmax within 2 hours
- Exhibits extensive tissue distribution, with preferred uptake into lung tissue
- Highly soluble in DMSO (≥ 100 mg/mL)
- Excreted through bile with mono- and di-hydroxy metabolites
Medchemexpress LLC Cinnarizine | 298-57-7 | MFCD00056037 | 99.0% | 25 MG
Cinnarizine (Standard) is an analytical standard. It is an orally active, effective and selective inhibitor of L-type calcium channel Cav1.3. This product is intended for research and analytical applications.
- Inhibits L-type calcium channel Cav1.3 with an IC50 of 1.5 μM.
- Crosses the blood-brain barrier to regulate calcium homeostasis and dopamine neurotransmission.
- Inhibits influx of calcium ions into smooth muscle cells, relaxing vascular smooth muscle.
- Improves cerebral circulation and reduces blood viscosity.
- Antagonizes dopamine receptors.
- Used in the study of vestibular vertigo, Meniere's disease, and cerebrovascular diseases.
Cayman Chemical THJ2201 N-(5-hydroxypentyl) metabolite, Purity: ≥98%, CAS: 1850409-16-3, 5 mg
An analytical reference standard categorized as a synthetic cannabinoid metabolite; a metabolite of THJ2201 and THJ 018; intended for research and forensic applications
Cayman Chemical AZD 3293, Purity: ≥98%, CAS: 1383982-64-6, 10 mg
An inhibitor of BACE1 and BACE2 (Kis = 0.4 and 0.8 nM, respectively); selective for BACE1 and BACE2 over cathepsin D, γ-secretase, and hERG (IC50s = 3,797, >25,000, and 4,700 nM, respectively); inhibits the secretion of Aβ40 in primary mouse and guinea pig neuronal cultures (IC50s = 0.61 and 0.31 NM, respectively), as well as in SH-SY5Y cells overexpressing human APP (IC50 = 0.08 nM); reduces plasma and brain levels of Aβ40 and brain levels of Aβ42 in mice at 50, 100, and 200 µmol/kg
Cayman Chemical CU-115, Purity: ≥98%, CAS: 2471982-20-2, 5 mg
A TLR8 antagonist (IC50 = 1.04 µM); selective for TLR8 over TLR7 (IC50 = >50 µM); inhibits increases in type I IFN transcriptional activity induced by 3p-hpRNA or G3-YSD in a luciferase reporter assay at 5 and 20 µM; decreases R-848-induced TNF-α and IL-1β production in THP-1 cells at 5 µM
Medchemexpress LLC Azide-PEG-azide | 95.0% | 10,000 Da (average) | 5 MG
Azide-PEG-azide is a bifunctional polyethylene glycol linker bearing azide groups at both termini, designed for use in click chemistry and bioconjugation workflows. The material is supplied as a polydisperse PEG with an average molecular weight of 10,000 Da and provides a hydrophilic, flexible spacer to connect molecular fragments, improving solubility and linker reach while enabling efficient azide-alkyne cycloaddition reactions.
- Bifunctional PEG linker with terminal azide groups.
- Average molecular weight 10,000 Da (polydisperse).
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
- Provides hydrophilic, flexible spacer to improve solubility and linker reach.
- Suitable for bioconjugation, PEGylation, and linker synthesis applications.
Medchemexpress LLC KPT-6566 | 881487-77-0 | 98.0% | 443.54 g/mol | C22H21NO5S2 | 25MG
KPT-6566 is a selective, covalent inhibitor of the prolyl isomerase PIN1 intended for laboratory research. It binds covalently to the catalytic site of PIN1, inhibiting enzyme activity and promoting PIN1 degradation; reported to induce DNA damage and produce antiproliferative effects in cancer cell models. Supplied as a solid with reported purity around 98.0% and commonly used in in vitro studies.
- Selective covalent inhibitor of PIN1.
- Promotes degradation of PIN1 and inhibits its enzymatic activity.
- Induces DNA damage and elicits antiproliferative effects in cell models.
- Supplied as a solid with typical purity of 98.0%.
- Soluble in DMSO and provided in multiple milligram sizes suitable for in vitro work.
- For research use only; not for human or diagnostic use.
![eMolecules 1338919-70-2 | Ambeed | 12H-Benzofuro[23-a]carbazole | 1g | 586457140 | A724699 | 257.292 | C18H11NO](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502484408.JPG-250.jpg)
eMolecules 1338919-70-2 | Ambeed | 12H-Benzofuro[23-a]carbazole | 1g | 586457140 | A724699 | 257.292 | C18H11NO
Medchem Express | Sibofimloc | 5mg | 446261879 | HY-12820 | 1616113-45-1 | MFCD28144726 | 649.693 | C35H39NO11
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Medchemexpress LLC Isotetrandrine | 477-57-6 | MFCD00236404 | 1 MG
Isotetrandrine is a bioactive component found in Stephania tetrandra. It is intended for research use only and not for sale to patients.
- Purity: ≥97.0%
- Molecular weight: 622.75
- Formula: C38H42N2O6
- Appearance: Solid
- Color: White to light yellow
- Structure classification: Alkaloids, alkaloid dimers
- Initial source: Plants, Menispermaceae, Stephania tetrandra S. Moore
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
Medchemexpress LLC GluR6 antagonist-1 | 323176-64-3 | 98.0% | 302.78 | 5 MG
GluR6 antagonist-1 is a benzothiophene derivative that acts as a GluR6 antagonist. It can be used for researching acute and chronic neurological disorders.
- Benzothiophene derivative
- Acts as a GluR6 antagonist
- Used for researching acute neurological disorders
- Used for researching chronic neurological disorders
Cayman Chemical GSK2018682, Purity: ≥95%, CAS: 1034688-30-6, 10 mg
An S1P1 and S1P5 receptor agonist; selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4 receptors; efficacious in a mouse model of EAE
Apexbio Technology LLC Bay 11-7821 (BAY 11-7082)(Synonyms: BAY 11-7082, BAY-11-7082, BAY 117082, BAY11-7082, NF-kappaB inhibitor BAY 11-7082), 100mg, CAS: 19542-67-7.
Bay 11-7821 (also known as BAY 11-7082 CAS 19542-67-7) is a selective inhibitor of I B kinase (IKK) exhibiting an IC50 of 10 M It suppresses TNF -mediated phosphorylation of I B- thereby blocking NF- B activation and subsequent expression of adhesion molecules including E-selectin VCAM-1 and ICAM-1 Independent of NF- B inhibition Bay 11-7821 can induce cell death in B-cell lymphoma and leukemic T cells and suppresses the NALP3 inflammasome activation in macrophages Thus it serves as an important tool for studies on inflammatory signaling pathways and apoptosis regulation
Medchemexpress LLC 4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid | 29553-70-6 | 99.6% | 287.22 | C14H9NO6 | 25MG
4-CPPC is a small-molecule research reagent that functions as a reversible, selective inhibitor of macrophage migration inhibitory factor-2 (MIF-2). It is intended for in vitro biochemical and cell-based research and is supplied with characterization and high reported purity; not for human use.
- Reversible, selective MIF-2 inhibitor with reported Ki/IC50 values of 431 μM for MIF-1 and 33 μM for MIF-2.
- High purity (99.6%) suitable for research applications.
- Molecular formula C14H9NO6 and molecular weight 287.22 g/mol.
- Soluble in DMSO; also offered as a 10 mM DMSO solution option.
- Available in multiple small pack sizes for laboratory use.
- For research use only, not intended for human or clinical use.
Medchemexpress LLC Sirt2/6-in-1 (compound 5) | 1214468-35-5 | MFCD11667663 | 99.8% | 410.40 g·mol⁻¹ | C19H14N4O5S | 5MG
SIRT2/6-IN-1 is a small-molecule research inhibitor that targets sirtuin deacetylases SIRT6 and SIRT2. It inhibits both enzymes with micromolar potency and has demonstrated cellular effects including increased H3K9 acetylation, enhanced glucose uptake, and reduced TNF-α secretion. The compound is supplied as a powder for laboratory research and is soluble in DMSO and several in vivo vehicle formulations.